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Zithromax, tablets 
Vidal 
AZITHROMYCIN 
Other dosage unit forms: capsules. 
Zithromax, tablets 
The price of Zithromax, tablets in pharmacies 

Macrolide antibiotic, is a representative azalides. Inhibits RNA-dependent protein synthesis of sensitive microorganisms. 

Active against Gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes / group A /); Gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp., Legionella pneumophila; anaerobic bacteria: Bacteroides fragilis. 

Zithromax is also active against Chlamydia trachomatis, Mycoplasma pneumoniae, Mycoplasma hominis, Treponema pallidum. 

Is also active against Toxoplasma gondii. 

Pharmacokinetics 
Rapidly absorbed from the gastrointestinal tract. Ingestion reduces the absorption of Zithromaxa. Cmax in plasma is reached after 2-3 hours. Rapidly distributed in tissues and biological fluids. 35% Zithromaxa metabolized in the liver by demethylation. More than 59% is excreted in the bile in unchanged form, about 4.5% - in the urine in unchanged form. 

DOSAGE 
Set individually according to nosology, disease severity and sensitivity of the pathogen.

Adults inside - 0.25-1 g 1 time / day; children - 5-10 mg / kg 1 time / day. Course duration 2-5 days. 

Angina 
Angina is called inflammation of the tonsils, usually of bacterial etiology, proceeds with high fever and the manifestations of toxicity. Angina dangerous development of complications and therefore requires timely administration of antibacterial drugs and of bed rest .... 
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Drug Interactions 
While the use of ergot alkaloids can not exclude the risk of ergotism. 

At simultaneous application with warfarin Zithromax described cases of enhancement of the effects of the latter. 

With simultaneous use of digoxin or digitoxin with Zithromaxom may significantly increase the concentration of cardiac glycosides in plasma and risk of glycoside intoxication. 

While the use of disopyramide, a case of ventricular fibrillation. 

While the use of lovastatin described cases of rhabdomyolysis. 

At simultaneous application with rifabutin increases risk of neutropenia and leukopenia.

With simultaneous use of disturbed metabolism of cyclosporine which increases the risk of adverse and toxic reactions caused by cyclosporine. 

Pregnancy and lactation 
Zithromax crosses the placental barrier. Application of pregnancy is only possible in cases where the intended benefits to the mother outweighs the potential risk to the fetus. 

If necessary, use Zithromaxa during lactation should decide on the termination of breastfeeding. 

SIDE EFFECTS 
From the digestive system: nausea, vomiting, flatulence, diarrhea, abdominal pain, transient elevation of liver enzymes; rarely - cholestatic jaundice. 

Allergic reactions: seldom - a skin rash, angioedema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis. 

Dermatological reactions: seldom - photosensitivity. 

Co CNS: dizziness, headache; rarely - drowsiness, weakness. 

Hematopoietic system: rarely - leukopenia, neutropenia, thrombocytopenia. 

On the part of the cardiovascular system: rarely - pain in the chest. 

Genitourinary: vaginitis; rarely - candidiasis, nephritis, increased BUN. 

Other: rarely - hyperglycemia, arthralgia. 

INDICATIONS 
Infectious-inflammatory diseases caused by microorganisms sensitive to Zithromaxu, including bronchitis, pneumonia, infections of skin and soft tissue, otitis media, sinusitis, pharyngitis, tonsillitis, gonorrheal and negonoreyny urethritis and / or cervicitis, Lyme disease (borreliosis). 

CONTRAINDICATIONS 
Hypersensitivity to Zithromaxu and other macrolide antibiotics. 

SPECIAL NOTES 
Not recommended for use in patients with impaired liver function. 

Used with caution in renal impairment. 

Zithromax should take no less than 1 hour before or 2 hours after eating or antacids. 

Otolaryngology 
otitis media 
snoring 
diseases of the ear 
Sore throat 
If the kidney function 
Used with caution in renal impairment. 

If abnormal liver function 
Not recommended for use in patients with impaired liver function. 

USE IN CHILDREN 
Application is possible according to the dose regimen. 
Description of the drug Zithromax is based on the approved instructions for use and approved by the manufacturer. 
 
 
 
  Zithromax 

Mode of action: 
Broad-spectrum antibiotic. Is the first representative of a new subgroup of macrolide antibiotics - azalides. When you create inflammation in high concentrations has a bactericidal effect. 
To Zithromaxu susceptible gram-positive cocci: Streptococcus pneumoniae, Str.pyogenes, Str.agalactiae, streptococci groups CF and G, Staphylococcus aureus, S.viridans; Gram-negative bacteria: Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, B.parapertussis, Legionella pneumophila, H.ducrei, Campylobacter jejuni, Neisseria gonorrhoeae and Gardnerella vaginalis; some anaerobic bacteria: Bacteroides bivius, Clostridium perfringens, Peptostreptococcus spp; and Clamydia trachomatis, Mycoplasma pneumoniae, Ureaplasma urealyticum, Treponema pallidum, Borrelia burgdoferi. Zithromax inactive against Gram-positive bacteria resistant to erythromycin. 

Indications: 
Infections of the upper respiratory tract and the upper respiratory tract caused by susceptible pathogens: pharyngitis, tonsillitis, laryngitis, sinusitis, otitis media; scarlet fever; infections of the lower respiratory tract: pneumonia (including atypical, exacerbation of chronic) bronchitis; infections of skin and soft tissue: erysipelas, impetigo, secondarily infected dermatoses; Urinary Tract Infection: gonorrheal and negonoreyny urethritis, cervicitis; Lyme disease (initial stage - erythema migrans), gastric ulcer and duodenal ulcer associated with Helicobacter pylori (in combination therapy). 

Contraindications: 
Hypersensitivity (including to other. Macrolides), liver and / or renal failure, lactation. Precautions - pregnancy (can be used in cases where the benefits of its use is much higher than the risk always exists when using any drug during pregnancy), arrhythmia (ventricular arrhythmias and prolongation of the interval QT), children under the age of 16 years (in / in tablets, capsules), children with severe liver or kidney function, newborn (oral suspension). 

Dosage and administration: 
Inside for 1 hour before or 2 hours after eating 1 time per day. 
Adults with infections of the upper and lower respiratory tract - 0.5 g / day for 1 reception for 3 days (dose rate - 1.5 g). 
For infections of skin and soft tissue - 1 g / day on the first day for 1 admission, followed by 0.5 g / day every 2 to 5 day (dose rate - 3 g). 
In acute infections, urinary organs (uncomplicated urethritis or cervicitis) - single 1 g 
When Lyme disease (Lyme disease) for the treatment of stage I (erythema migrans) - 1 g on the first day and 0.5 g daily from 2 to 5 day (dose rate - 3 g). In gastric ulcer and duodenal ulcers associated with Helicobacter pylori - 1 g / day for 3 days in a combination therapy of H. pylori. 
Children prescribed rate of 10 mg / kg, 1 time a day for 3 days or the first day - 10 mg / kg, followed by 4 days - 5-10 mg / kg / day for 3 days (course dose - 30 mg / kg). 
In the treatment of erythema migrans children dose - 20 mg / kg on the first day and 10 mg / kg at 2 and 5 days. B / in the treatment of pneumonia - 0.5 g once for at least two days, subsequently - inside the capsule 2 (0.25 g); course - 7-10 days. 
When pelvic infection - a / c, 0.5 g once, in the future - inside, 2 capsules (0.25 g); Course - 7 days. 

Date of transition to oral intake depends on the dynamics of clinical and laboratory parameters. 

Terms of solution for / in the 0.5 g diluted in 4.8 ml of water for injection and mix until dissolved. For i / v infusion: dissolve 0.5 g of 5% dextrose, 0.9% sodium chloride solution, Ringer's solution to 500 ml (concentration: 1 mg / ml, administered over 3 hours) to 250 ml (concentration: 2 mg / ml , be administered over 1 hour). 

Adverse effects: 
From the digestive system: ingestion - diarrhea (5%), nausea (3%), abdominal pain (3%); 1% or less - dyspepsia, flatulence, vomiting, melena, cholestatic jaundice, increased activity of "liver" enzymes; In addition, children - constipation, anorexia, gastritis, candidiasis of the oral mucosa (with / in the introduction). From the CCC: palpitations, chest pain (1% or less). 
The nervous system: dizziness, headache, vertigo, drowsiness; children - a headache (for the treatment of otitis media), hyperkinesia, anxiety, neurosis, insomnia (1% or less). 
Genitourinary: vaginal candidiasis, nephritis (1% or less). 
Allergic reactions: rash, photosensitivity, angioedema; at / in the introduction - bronchospasm (1% or less). 
Local reactions: with / in the introduction - the pain and inflammation at the injection site. 
Other: fatigue; children - conjunctivitis, pruritus, urticaria; at / in the introduction - a change of taste (1% or less). 

Overdose. 
Symptoms: severe nausea, temporary hearing loss, vomiting, diarrhea. 

Special instructions: 
When you miss taking a dose of the missed dose should be taken as soon as possible, and the next - with an interval of 24 hours. Observe break in 2 hours, while the use of antacids. Not been definitively established security purposes (a / c, as well as in the form of capsules and tablets) Zithromaxa in children and adolescents younger than 16 years (possibly use as an oral suspension in children 6 months and older). After discontinuation of treatment of hypersensitivity reactions in some patients can be maintained, which requires specific therapy under medical supervision. 

interaction: 
Antacids (aluminum and magnesium-containing), ethanol and food slow down and reduce the absorption. The joint appointment of warfarin and Zithromaxa (at normal doses) changes in prothrombin time have been identified, however, given that the interaction of macrolides and warfarin may be increased anticoagulation effect, patients should be closely monitored in prothrombin time. Digoxin: increased digoxin concentrations. Ergotamine and dihydroergotamine: gain of toxic action (vasospasm, dysesthesia). Triazolam: decrease in clearance and increase the pharmacological action triazolana. Slows down and increases the plasma concentration and toxicity of cycloserine, indirect anticoagulants, methylprednisolone, felodipine, as well as drugs that are subject to microsomal oxidation (carbamazepine, terfenadine, cyclosporine, geksobarbital, ergot alkaloids, valproic acid, disopyramide, phenytoin, bromocriptine, phenytoin, oral hypoglycemic agents , theophylline, and others. xanthine derivatives) - due to the inhibition of microsomal oxidation in hepatocytes Zithromaxom). Linkozaminy weaken the effectiveness of tetracycline and chloramphenicol - strengthen. Pharmaceutically compatible with heparin. 

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storage Conditions 
Store in a dry, dark place at a temperature not exceeding 25 ° C. 
The drug should be stored out of the reach of children. 

Shelf Life 
2 years. 
Do not use the medication after the expiry date printed on the package.