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Amoxil 

Name: Amoxil (Amoxil) 


Mode of action: 
Amoxicillin - semisynthetic aminopenicillin, has a bactericidal effect with optimal spectrum of antimicrobial activity, is not sensitive to mikoroorganizmam that can produce penicillinase. 
Amoxicillin / clavulanate - protected penicillin with high efficiency action against many bacteria, the advantage is the presence of clavulanic acid, which makes the drug-resistant? Lactamases (penicillinase). Clavulanic acid is a competitive irreversible inhibition of beta-lactamases, which allows also to reduce the phenomenon of cross-resistance to antimicrobial agents. 

drug amoxil

Has an active effect against many microorganisms, including: 
Gram (+) aerobes: Bacillus anthracis, Enterococcus (faecalis, faecium), Listeria monocytogenes, species Corynebacterium, Nocardia asteroides, Staph. aureus, coagulase (-) staphylococci (including Staph. epidermidis), Str. agalactiae, Str. pneumoniae, Str. pyogenes, species Str. viridans; 


gram (+) anaerobic bacteria: Clostridium, peptokokki, species Peptostreptococcus; 


gram (-) aerobes: Bordetella pertussis, species Brucella, E. coli, Gardnerella vag., Haemophilus influenzae, Helicobacter pylori, Klebsiella, Legionella, Moraxella catarrhalis (Branhamella catarrhalis), N. gonorrhoeae, N. meningitidis, Pasteurella multocida, Proteus mirabilis , Pr. vulgaris, species of Salmonella, types of Shigella, Vibrio vibroion, Yersinia enterocolitica; 

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gram (-) anaerobic bacteria: species Bacteroides (including Bacteroides fragilis), species Fusobacterium; 
other bacteria: Borrelia burgdorferi, Chlamydia, Leptospira icterohaemorrhagiae, pale treponema. 

Amoxicillin unprotected no effect on the bacteria that produce beta-lactamase, which makes certain bacteria insensitive to amoxicillin alone. 
Almost immediately absorbed from the gastrointestinal tract, the mean Cmax - 30-45minut. Bioavailability is 90% when administered orally. Period T? is 60-90 minutes. Connection with blood proteins and small amounts of up to 20% for amoxicillin and 30% for clavulanic acid. The drug is metabolized in the liver. Buy cheap amoxil without prescription actively distributed in the skin, fat, muscle tissue, abdominal, hepatobiliary system, and is also detected in the synovial, peritoneal fluids. The elimination takes place through the kidneys. Withdrawal of the drug mainly in unchanged form in urine during the first six hours. 

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as to determine the doses and methods of its application. 

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amoxil 500 mg

Semisynthetic aminopenicillin broad-spectrum bactericidal effect. It is used for infections caused by susceptible microorganisms to amoxicillin, including infections of the respiratory system; gastrointestinal tract; genitourinary system; skin and soft tissue. In combination with metronidazole or clarithromycin is used for treating digestive tract diseases associated with Helicobacter pylori. Amoxil is administered orally (regardless of the meal). Drug dosing regimen set individually, taking into account the characteristics of the disease.

Amoxil (AMOXIL) 

The pharmacological properties of the drug Amoxil: 

Farmakokinetika.Posle oral amoxicillin well absorbed, reaching Cmax in serum after 2 h after administration. T1 / 2 - 1.5 hours. Provided excreted unchanged by the kidneys (60-70%). 

Contraindications Amoxil: 

hypersensitivity to amoxicillin trihydrate and / or other components of the drug, as well as other antibiotics penicillin. Patients with hypersensitivity to cephalosporin antibiotics should consider the possibility of cross allergies; infectious mononucleosis, lymphatic leukemia; lactation period; Children up to age 1 year. 


Side effects of Amoxil: 

when using Amoxil possible: 

Allergic reactions: skin rash, itching, hives, flushing, fever, rarely - erythema multiforme, Stevens - Johnson syndrome, toxic epidermal necrolysis, hyperkeratosis of the skin, bullous and exfoliative dermatitis, eczema, enanthema, anaphylactic shock and angioedema, serum sickness, vasculitis; 

Gastrointestinal: nausea, vomiting, diarrhea, loss of appetite, dry mouth, taste disturbance, bloating, discomfort, and abdominal pain, colitis (including pseudomembranous, hemorrhagic), tongue discoloration (black, "hairy" tongue); 

Urinary system: rarely - interstitial nephritis; 

On the part of hematopoiesis: rarely - hemolytic anemia, oboratimaya thrombocytopenia, eosinophilia, reversible leukopenia (including neutropenia, agranulocytosis), increased prothrombin time; 

Liver and biliary system: a moderate increase in liver enzymes, rarely - hepatitis, jaundice; 

 

Special instructions for use of the drug Amoxil: 
Children. The drug is contraindicated for use in children under the age of 1 year. 

Ability to influence the rate of reaction in the management of motor vehicles, or work with other mehanizmami.Sleduet with caution to take the drug to persons driving or working with other mechanisms, due to the risk of possible adverse reactions of the nervous system. 
Forced diuresis reduces the concentration of amoxicillin in serum by raising its elimination. 
With the simultaneous use with allopurinol may increase the frequency of allergic reactions of the skin. 
Simultaneous treatment with antacids reduces the absorption of amoxicillin. 
When concomitantly with anticoagulants is necessary to monitor the prothrombin time because of increased likelihood of bleeding. 
The appearance of diarrhea may reduce the absorption of other drugs and efficacy Amoxil. 
Amoxil may decrease the concentration of estradiol in the urine of pregnant women. 


Overdose of the drug Amoxil: 
Symptoms: nausea, vomiting, diarrhea, disruption of water and electrolyte balance. 

Treatment: gastric lavage, the use of enterosorbents (activated carbon), saline laxatives, correction of water and electrolyte balance; if necessary, apply hemodialysis.

Storage conditions of the drug Amoxil: 

at a temperature not exceeding 25 ° C.

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